| 背景 |
CCR8 is a T cell specific G-protein-coupled, 7-transmembrane receptor. Human CCR8 is expressed only in lymphoid organs and in particular in the thymus. Mouse CCR8 is also expressed mainly in the thymus. CCR8 is a CCL18 receptor. CCL18 bound with high affinity to CCR8 and induced its internalization. Human CCL1, the known endogenous CCR8 ligand, and CCL18 competed for binding to CCR8-transfected cells. CCR8 was shown to function as a HIV-1 coreceptor in primary human thymocytes for several HIV-1 strains. vMIP-1 and CCL1 are able to trigger a CCR8-mediated rescue from dex-induced apoptosis by an extracellular-regulated kinase (ERK)-dependent mechanism . |
