| 背景 |
CDC25 phosphatases, which are believed to be important regulators of cell cycle progression, dominate entry into mitosis by regulating the activation of CDK1/cyclin B. Catalyzed by these dual specificity phosphatases, cyclin/CDKs are dephosphorylated and actived after removal of inhibitory phosphate groups from Thr14 and Tyr15. In higher-eukaryotic cells, three isoforms of CDC25 denoted CDC25A, CDC25B and CDC25C exist. While Cdc25A is involved in the regulation of the Gl-to-S phase transition, Cdc25B and Cdc25C play an important role at the G2-to-M transition. Cdc25C interacts with two isoforms of 14-3-3, namely 14-3-3ε and 14-3-3ζ. The binding of 14-3-3 proteins to Cdc25 is high during interphase and absent during mitosis. |
