| 背景 |
NrCAM (neuron-glia-related cell-adhesion molecule) is a transmembrane protein composed of six Ig-like domains and five FnIII repeats in the extracellular region, plus a highly conserved cytoplasmic tail. It is expressed primarily, although not solely, in the nervous system and is involved in neuron-neuron and neuron-glial adhesion as well as directional signaling during axonal cone growth. NrCAM has been shown to be involved in several cellular processes in the central and peripheral nervous systems, including neurite outgrowth, axonal pathfinding and myelination, fasciculation of nerve fibers, and cell migration. |
