| 背景 |
SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is ubiquitously expressed in various tissues and cell types. SHP-2 and has been implicated in diverse signaling pathways including those initiated by growth factors such as PDGF, EGF, and IGF-1, cytokines such as IL-3, GM-CSF, and EPO, as well as insulin and interferon. SHP-2 has compound signaling functions. It appears to be involved in a variety of signal transduction processes, such as the Ras-Raf-MAP kinase, Jak-Stat, and PI3 kinase pathways. Within a single signaling pathway, SHP-2 may act at multiple sites to participate in the signal relay. |
