| 背景 |
Protein kinase C α is a serine/threonine kinase and a member of the conventional (classical) PKCs (cPKCs). This ubiquitously expressed PKC isotype is activated in response to many different kinds of stimuli and translocates from cytosol to the specialized cellular compartments (nucleus, focal adhesion, caveolae, etc.) where it is presumed to work. Therefore, PKCα has been implicated in a variety of cellular functions including proliferation, apoptosis, differentiation, motility, and inflammation. Upon stimulation, PKCα translocates from cytosol to a so-called particulate fraction and phosphorylates a variety of substrates depending on the types of stimuli and cells. |
