| 背景 |
TBP-like factor (TLF, also known as TBPL1 and TRF2) is the only member of TBP family which lacks the ability to bind the TATA box. TBP is a key component of the eukaryotic transcription initiation machinery. TLF can interact with TFIIA and TFIIB, forms a complex with TFIIA in HeLa cells but can also interact with TFIIA-like factor (ALF), which is a germ cell-specific paralog of TFIIA. TLF is also shown to negatively modulate transcription by sequestering TFIIA. TBPL1 is crucial for spermiogenesis and supposed to be significant in expression of developmentally regulated genes. |
