PDD00017273

目录号：S8862 批次号：S886201

打印

化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C23H26N6O4S2
分子量 514.62 CAS号 1945950-21-9
Solubility (25°C)* 体外 DMSO 100 mg/mL 194.31 mM
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 PDD00017273是有效的、选择性的poly (ADP ribose) glycohydrolase (PARG)抑制剂，IC50为26 nM. 它对PARG的选择性比对其他离子通道、酶和受体如PARP1和ARH3高350倍以上。
靶点
PARG [1]
(Cell-free assay)
26 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

PDD00017273在文献中得到引用

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) [ Mol Cell, 2024, S1097-2765(24)00864-5] PubMed: 39536748
SNF2L suppresses nascent DNA gap formation to promote DNA synthesis [ Nucleic Acids Res, 2024, gkae903] PubMed: 39413208
CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer [ Cell Death Discov, 2024, 10(1):278] PubMed: 38862485
The three-dimensional structure of the EBV genome plays a crucial role in regulating viral gene expression in EBVaGC [ Nucleic Acids Res, 2023, 10.1093/nar/gkad936] PubMed: 37889078
The regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells [ Cell Death Differ, 2023, 10.1038/s41418-023-01118-z] PubMed: 36750717
Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation [ Cell Death Dis, 2023, 14(7):435] PubMed: 37454129
Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications [ J Vis Exp, 2023, (194).] PubMed: 37154555
PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis [ bioRxiv, 2023, 2023.07.05.547847] PubMed: 37461649
The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity [ Nat Commun, 2022, 13(1):187] PubMed: 35039491
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation [ Mol Cell, 2022, S1097-2765(22)00085-5] PubMed: 35219381

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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