Sodium oxamate

目录号：S6871 批次号：S687103

化学数据

	别名	SO, oxamate sodium, Aminooxoacetic acid sodium salt, Oxamic acid sodium salt	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₂H₂NNaO₃
	分子量	111.03	CAS号	565-73-1
Solubility (25°C)*	体外	Water	22 mg/mL 198.14 mM
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid)是一种 lactate dehydrogenase (LDH) 的抑制剂，可特异性地抑制LDH‑A。Sodium oxamate (SO) 通过下调 CDK1/cyclin B1 途径诱导G2/M细胞周期停滞，并通过增加线粒体内 ROS 的生成来促进凋亡。

靶点

LDHA ^[1]

ROS ^[2]

CDK1 ^[2]

参考文献

[4] Qu J, et al. Int J Biol Sci. 2021 Jul 2;17(11):2756-2769.

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Sodium oxamate在文献中得到引用

Protein lactylation within the nucleus independently predicts the prognosis of non‑specific triple‑negative breast cancer [ Oncol Lett, 2025, 29(2):72]	PubMed: 39628828
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization [ Cancer Cell, 2024, S1535-6108(24)00119-3]	PubMed: 38640932
GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression [ J Exp Clin Cancer Res, 2024, 43(1):105]	PubMed: 38576043
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis [ J Adv Res, 2024, S2090-1232(24)00025-0]	PubMed: 38219869
Lactylation drives hCG-triggered luteinization in hypoxic granulosa cells [ Int J Biol Macromol, 2024, 280(Pt 4):135580]	PubMed: 39322166
HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cells to facilitate renal functional recovery from kidney ischemia/reperfusion injury [ Cell Mol Life Sci, 2024, 81(1):404]	PubMed: 39277835
Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer [ J Transl Med, 2024, 22(1):676]	PubMed: 39044184
Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma [ Cancers (Basel), 2024, 16(21)3606]	PubMed: 39518046
IL-6-Derived Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37]	PubMed: 38551584
IL-6-Driven Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37]	PubMed: 38551584

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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