II型糖尿病

造模剂

STZ

Citric acid

Sodium citrate dihydrate

Dexamethasone

Alloxan Monohydrate

Fructose

葡萄糖代谢

双胍类: Metformin HCl; Phenformin HCl

α-Glucosidase抑制剂: α-D-Glucose anhydrous; Acarbose; Miglitol; Butyl isobutyl phthalate; Voglibose; 1-Deoxynojirimycin

SGLT2抑制剂: Dapagliflozin; Canagliflozin; Tofogliflozin; Ipragliflozin; Ertugliflozin; Empagliflozin

肝脏糖异生: SR-18292; GSK4112; Metformin HCl

胰岛素促泌剂 (A)

一代磺酰脲类 ^[1]: Acetohexamide; Tolbutamide; Chlorpropamide

二代磺酰脲类 ^[2] ^[3]: Glyburide; Glipizide; Gliquidone; Gliclazide; Glimepiride

Glinides ^[4]: Mitiglinide Calcium; Repaglinide; Nateglinide

胰岛素促泌剂 (B)

DPP-4抑制剂: Linagliptin; Saxagliptin; Vildagliptin; Alogliptin; Sitagliptin

GLP-1激动剂: GLP-1; Dulaglutide; Liraglutide; Lixisenatide; Semaglutide Sodium; Danuglipron; Tirzepatide sodium

胰岛素增敏剂

TZDs ^[5] ^[6]: Pioglitazone; Rosiglitazone; Troglitazone; MSDC-0160

脂质GPCR激动剂: TUG-891; GSK137647A; GW9508

线粒体相关: Rosiglitazone maleate; Pioglitazone; Imeglimin Hydrochloride; MSDC-0602K Potassium; BC1618; 7ACC2

糖尿病血脂异常 ^[7]

Evolocumab

Bococizumab

Saroglitazar

Acipimox

Naringin

Clofibric Acid

Ginsenoside Re

Elafibranor

Fenofibrate

Simvastatin

Ezetimibe

Bezafibrate

pemafibrate

代谢组学 ^[8]

isoleucine

L-Leucine

L-Valine

L-Tyrosine

D-Phenylalanine

Glycine

β-Alanine

L-Glutamic acid monosodium salt

2-Hydroxybutyric acid

I型糖尿病

造模剂

STZ

Alloxan Monohydrate

Cycloheximide

Nicotinamide

发病机制

cholecalciferol

Levothyroxine sodium

T3

Hydroxychloroquine Sulfate

Acetaminophen

Cinnamaldehyde

Dopamine HCl

Bisphenol A

治疗

一级预防 ^[9]: Insulin; Insulin Degludec

二级预防 ^[9]: Insulin; Insulin Degludec; Nicotinamide; Teplizumab; cholecalciferol

辅助治疗: Metformin; Dapagliflozin; Empagliflozin; Exenatide Acetate; Semaglutide Sodium; Sotagliflozin

胰腺保护

Resveratrol

Ginsenoside Rg1

Allicin

Imatinib

Punicalagin

Simvastatin

Tropisetron

抗炎&抗氧化

Curcumin

Chamomile Extract

Hesperetin

Hesperidin

Maslinic acid

Zeaxanthin

GSH

代谢组学

Cholesterol

Creatinine

Sodium Bicarbonate

Arachidonic acid

Chenodeoxycholic Acid

Eicosapentaenoic Acid

isoleucine

L-Leucine

L-Valine

Progesterone

Taurocholic acid sodium salt

Taurodeoxycholic acid sodium hydrate

Tauroursodeoxycholic Acid

Ursodeoxycholic acid sodium

并发症

骨病: Collagen; Morroniside

肾病: Brusatol; Artemether; Silymarin; Ursolic Acid

心血管疾病: Acetylcholine Chloride; DHA

心肌病: Luteolin; Meisoindigo; pemafibrate

相关化合物库

Anti-diabetic Compound Library

Human Endogenous Metabolite Compound Library

Carbohydrate Metabolism Compound Library

Metabolism Compound Library

Mouse Metabolite Compound Library

MAPK Inhibitor Library

NF-κB Signaling Compound Library

PI3K/Akt Inhibitor Library

Obesity Compound Library

参考文献