代谢
- 肿瘤糖酵解 [1]
-
- HKII抑制剂
- 2-DG
- Lonidamine
- Bromopyruvic acid
-
- PFKFB3抑制剂
- PFK15
- 3PO
- PFK158
- KAN0438757
-
- PKM2抑制剂
- PKM2 inhibitor
- Shikonin
- Alkannin
-
- LDHA抑制剂
- Sodium oxamate
- -GNE-140
- GSK 2837808A
- AZ-33
- FX11
- 脂代谢重编程 [2]
-
- SCAP/SREBPs抑制剂
- PF 429242
- Fatostatin
- Cinobufotalin
- Betulin
-
- SLC25A1抑制剂
- CTPI-2
-
- ACLY抑制剂
- BMS303141
- Bempedoic acid
- NDI-091143
-
- ACSS2抑制剂
- Firsocostat
- TOFA
- ND646
-
- FASN抑制剂
- Denifanstat
- C75
- TVB-3166
- Orlistat
-
- LXR/ABCA1激动剂
- GW3965 HCl
- LXR-623
- SR9243
- 谷氨酰胺代谢 [3]
-
- GLS1/2抑制剂
- Telaglenastat
- BPTES
- GK921
-
- Glutamine耗竭
- 4-PBA
-
- ASCT2/SLC1A5抑制剂
- V-9302
- GPNA hydrochloride
-
- Glutamine拮抗剂
- JHU-083
- 6-Diazo-5-oxo-L-norleucine
- JHU395
-
- GDH抑制剂
- EGCG
- R162
- -Epicatechin gallate
- GW5074
- Bithionol
-
- Aminotransferase抑制剂
- AOA hemihydrochloride
- 线粒体代谢 [4]
-
- KGDH抑制剂
- Devimistat
- 4-Methyl-2-oxovaleric acid
-
- PDH抑制剂
- DCA
- Devimistat
- KPLH1130
-
- OXPHOS抑制剂
- IACS-010759
- Oligomycin A
- FCCP
- CCCP
- Lixumistat
- 肠道微生物代谢 [5]
- 核苷酸代谢 [6]
-
- DHODH抑制剂
- Leflunomide
- Teriflunomide
- Brequinar
- Orludodstat
-
- IMPDH1/2抑制剂
- Mycophenolic acid
- Mizoribine
- Merimepodib
- 精氨酸代谢 [7]
-
- PRMT5抑制剂
- EPZ015666
- Pemrametostat
- LLY-283
- GSK591
- Onametostat
-
- PAD4抑制剂
- Cl-amidine
- GSK484 HCl
- BMS-P5
-
- ASS1抑制剂
- Cisplatin
-
- Arginase抑制剂
- Nor-NOHA acetate
- Polymyxin B sulphate
- L-Norvaline
- BEC HCl
- 色氨酸代谢 [7]
-
- GCN2抑制剂
- GCN2iB
- 丝氨酸&甘氨酸代谢 [7]
-
- SHMT2抑制剂
- SIS17
- 相关化合物库
- Metabolism Compound Library
- Anti-cancer Metabolism Compound Library
- Glutamine Metabolism Compound Library
- Carbohydrate Metabolism Compound Library
- Lipid Metabolism Compound Library
- Human Endogenous Metabolite Compound Library
- Glycolysis Compound Library
- Gut Microbial Metabolite Library
- Mouse Metabolite Compound Library
- Mitochondria-Targeted Compound Library
参考文献
- [1] Sheng H, et al. Recent Pat Anticancer Drug Discov. 2016;11(3):297-308.
- [2] Cheng, C., et al. Cancer Commun 38, 27 (2018).
- [3] Li T, et al. Adv Exp Med Biol. 2018;1063:13-32.
- [4] Luo Y, et al. Int J Mol Sci. 2020 Aug 5;21(16):5598.
- [5] HAN Ruiying, et al. Microbiology China, 2021, 48(11): 4261-4274.
- [6] Mullen, N.J., Singh, P.K. Nat Rev Cancer 23, 275–294 (2023).
- [7] Qiu H, et al. Clin Nutr. 2023 Aug;42(8):1521-1530.
